United States – The link between excessive marijuana consumption and the development of psychotic behavior continues to be a pressing issue among researchers. Psychotic episodes pose significant risks, often leading individuals to seek hospitalization for treatment, as reported by HealthDay.
Antipsychotics Offer New Hope
A recent study suggests that immediate administration of specific antipsychotic medications could offer a lifeline to individuals who abuse cannabis and subsequently experience their first psychotic episode.
Promising Findings and Recommendations
Led by Dr. Alexander Denissoff and his team from the University of Turku in Finland, the study underscores the importance of early intervention with second-generation, long-acting injectable antipsychotics to reduce hospitalization rates.

Investigating Effectiveness
Tracking 1,820 individuals who had experienced their initial psychosis episode alongside cannabis abuse disorder, the study found a significant reduction in “psychotic relapse” hospitalizations among those receiving antipsychotic treatment compared to those without.
Comparative Effectiveness of Antipsychotics
Risperidone was identified as the treatment that most reduced hospitalization of the patient during relapse whereas aripiprazole, clozapine, and paliperidone were nearly equally effective. The results sing the praises of individualized medicines for risky individuals.

Addressing Multiple Psychotic Episodes
The study emphasizes the importance of consistent antipsychotic use for individuals experiencing multiple psychotic episodes related to cannabis abuse, as it significantly reduces the likelihood of further episodes, as reported by HealthDay.
Tailored Treatment Approaches
Clozapine demonstrated notable effectiveness for individuals at risk of hospitalization due to substance use, suggesting the need for personalized treatment strategies based on individual needs and responses.
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